Hantzsch Dihydropyridine Synthesis Mechanism | Organic Chemistry
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Hantzsch Dihydropyridine Synthesis Mechanism | Organic Chemistry
The Hantzsch pyridine synthesis involves the condensation of two equivalents of a β-dicarbonyl compound, one equivalent of an aldehyde and one equivalent of ammonia. The immediate result from this three-component coupling, 1,4-dihydropyridine, is easily oxidized to a fully substituted pyridine. Saponification and decarboxylation of the 3,5 ...
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