Golden Gate method enables fully-synthetic engineering of therapeutically relevant bacteriophages

Bacteriophages have been used therapeutically to treat infectious bacterial diseases for over a century. As ...
BMJ

Development and validation of clinical vignettes to inform an educational intervention for physiotherapists to detect serious pathologies: a mixed-methods study

Objectives To develop and validate educational clinical vignettes (CVs) based on real-life patients with serious pathology from the disciplines of oncology, internal medicine and orthopaedics that are ...
chromatographyonline

Analysis of 40 Per- and Polyfluoroalkyl Substances by US EPA Method 1633 Part 1: Method Development and Verification with Quality Control Samples

Download Part 1 now to explore method optimization strategies, validation protocols, and best practices for reliable PFAS quantification. Parts 2–4 will cover additional sample matrices including ...
The New York Times

I developed NBA players for a decade. This new training method can help anyone

Editor’s note: This story is part of Peak, The Athletic’s desk covering leadership, personal development and performance through the lens of sports. Follow Peak here. Joe Boylan worked in the NBA for ...
C&EN

Implementation of the QbD Approach to the Analytical Method Development and Validation for the Estimation of the Treprostinil Injection Dosage Form by RP-HPLC

Article subjects are automatically applied from the ACS Subject Taxonomy and describe the scientific concepts and themes of the article. Despite its high cost, the role of treprostinil in managing ...
jnis.bmj

Development and validation of an explainable machine learning prediction model for futile recanalization after mechanical thrombectomy in acute large vessel occlusion stroke

Background Mechanical thrombectomy (MT) is the primary treatment for acute ischemic stroke (AIS) caused by large vessel occlusion (LVO). However, the likelihood of futile recanalization (FR) at 90 ...
Frontiers

Development and validation of a deep learning-enhanced prediction model for the likelihood of pulmonary embolism

Background: Pulmonary embolism (PE) is a common and potentially fatal condition. Timely and accurate risk assessment in patients with acute deep vein thrombosis (DVT) is crucial. This study aims to ...
BMJ

Oxford Vaccine Hesitancy Scale (OVHS): a UK-based and US-based online mixed-methods psychometric development and validation study of an instrument to assess vaccine hesitancy

Objectives To describe the development, validation and reliability of the Oxford Vaccine Hesitancy Scale (OVHS), a new instrument to assess vaccine hesitancy in the general population. Design ...