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ALS nerve damage can occur from a TDP-43 mutation (M337V). This damage happens without TDP-43 protein clumps, challenging prior beliefs. The mutation impairs nerve cell viability, transport, and ...

Abstract: A large number of research groups across the world image and study the transport of various neuronal organelles of model organisms like C.elegans due to its clinical significance. These ...

Introduction: Early neurorehabilitation after cerebral ischemia can influence neural remodeling. Forced exercise initiated within 6 hours post-stroke enhances long-term recovery but aggravates acute ...

Seeking students to contribute to research exploring motor-disease protein complexes and their role in intracellular transport, as they relate to disease initiation and the aging process, and the ...

Stathmin-2 is a neuron-specific protein essential for the maintenance of axonal health and muscle innervation, whose normal expression is lost in many neurodegenerative diseases. Its expression is ...

Researchers found that inhibiting GSK-3 led to less defects in the axonal transport process and less neuronal cell death, while inhibiting ERK1 led to more transport problems and more cell death. A ...

Indiana University researchers in the College of Arts and Sciences in Bloomington have identified a missing link that can help protect the brain from aging. Carnegie Mellon University's Jessica Zhang ...

ABSTRACT: Neurodegenerative diseases (NDDs) pose significant medical challenges, leading to progressive neuronal loss and functional decline. Current treatments primarily focus on symptom management ...

Sensory synapses are characterized by electron-dense presynaptic specializations, so-called synaptic ribbons. In cochlear inner hair cells (IHCs), ribbons play an essential role as core active zone ...

Our findings suggest that at least one type of vesicles, those containing transferrin receptor, travel exclusively to dendrites and are excluded from axons because the kinase MARK2 phosphorylates the ...