The type III secretion system (T3SS) is a sophisticated molecular apparatus that many Gram‐negative bacterial pathogens deploy to inject effector proteins directly into host cells. This machinery ...

UMass Amherst biochemists are mapping the molecular structure of a needle-like tool used by bacteria to invade human and mammalian cells to cause such diseases as plague and dysentery. Of particular ...

Cryo-electron microscope reconstruction of the binding of a human anti-PcrV Fab antibody (yellow) to a PcrV pentamer (blue) of the type III secretion system (T3SS) of Pseudomonas aeruginosa. The ...

Swallow the wrong microbe, and you might end up in the hospital with a needle or two in your arm — and plenty of itty-bitty bacterial needles poking at you from the inside. That’s because many ...

Six years ago, Michael Niederweis, Ph.D., described the first known toxin of the deadly pathogen Mycobacterium tuberculosis (Mtb), an exotoxin that had gone undetected for 132 years. Now Niederweis ...