Phosphatidate phosphatase (PAP) enzymes play a pivotal role in lipid metabolism, acting as a control point that directs metabolic flux between membrane phospholipid synthesis and the production of ...
MD Anderson studies reveal how cancer cells rewire metabolism to spread. A glucose–fructose mix promotes colorectal metastasis via cholesterol pathways, while fatty-acid oxidation driven by ACBP ...
Faulty lipid regulation in CLL patients impairs T-cell function, affecting treatment outcomes and resistance to current therapies. Differences in lipid metabolism between CLL patients and healthy ...
Lipid metabolism has emerged as a central player in the progression and therapy resistance of breast cancer, particularly the aggressive subtype known as triple-negative breast cancer (TNBC). This ...
The raw material for de novo fatty acid synthesis is acetyl-CoA, which can be obtained via the citrate shuttle pathway or from acetic acid. ACC and FASN catalyze the conversion of acetyl-CoA into ...
Image Caption: Dysregulation of lipid metabolism promotes EMT (by Figdraw). Down-regulation of ELOVL2 promotes EMT in breast cancer by up-regulating expression of SREBP1/2. Genes & Diseases publishes ...
Mutations in the lipid transporter ABCA7 are known to elevate the risk of Alzheimer’s disease, but how they do so has been murky. Now, scientists led by Li-Huei Tsai at MIT in Cambridge, Massachusetts ...
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