Everyone inherits two copies of the APOE gene, one from each parent, meaning six combinations are possible: ε2 / ε2 is the ...

The FDA granted fast track status to VectorY’s VTx-002, an antibody gene therapy targeting TDP-43 protein aggregates in ALS.

Getting therapeutic drugs past the blood-brain barrier has long been a major challenge in treating brain diseases. Now, researchers have explored how cholesterol-modified heteroduplex oligonucleotides ...

This study revealed that, by binding to lipoproteins, cholesterol-conjugated heteroduplex oligonucleotides (Chol-HDOs) can remain in the bloodstream for longer and reach brain tissue much more ...