Researchers at the Icahn School of Medicine at Mount Sinai have characterized how cellular senescence—a biological process in ...

Replicative aging of human cells, the result of telomere shortening, is slower at physiological oxygen than at atmospheric oxygen, a difference now shown to be due to low oxygen impairing the ATM ...

Despite the importance of this cancer prevention program, a number of long-standing questions about replicative senescence remained unanswered. It wasn't clear which DNA damage signaling pathway ...

Cellular senescence is a process in which the cell cycle becomes permanently arrested, thereby inhibiting cell division, proliferation and growth. Various cellular stresses, such as DNA damage, ...

Cellular senescence is a state where cells permanently stop dividing but remain metabolically active, often in response to stress or damage. Senescent cells are known to play a key role in wound ...

“Overall, this study further demonstrates the utility of high-content morphological analysis as a tool for the identification of senescent cells.” “Overall, this study further demonstrates the utility ...

T cell senescence occurs in the TME, affecting cancer prognosis and immunotherapy efficacy. The TME induces T cell senescence through multiple pathways, including persistent stimulation by ...

From fruit flies that survive a mere two weeks to the giant tortoises of the tropics that can live for nearly 200 years, every species has an allotted life expectancy. But while an organism’s lifespan ...