Peripheral sensitization refers to the lowering of the threshold of excitability of sensory neurons, which leads to an amplified reaction to a specific external stimulus. Sensitization can be mediated ...

There are the unfortunate patients who develop pain hypersensitivity. These patients have a pain threshold that is lower than normal, and the duration of the pain response can become long-lived. There ...

The cell bodies of nociceptors—the primary sensory neurons specialized for detecting harmful stimuli—are housed in anatomical structures located outside the CNS, the trigeminal and dorsal root ganglia ...

Fig 2. Basic mechanisms of pain processes at peripheral, spinal, and supraspinal sites and influences of various peripheral mechanisms, including tumor cell– and immune cell–mediated release of ...