The big headlines on this release are efficiency, with OpenAI reporting that GPT-5.4 uses far fewer tokens (47% fewer on some tasks) than its predecessors).
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Hoth Therapeutics has deployed the OpenAI API to support IND-enabling development of HT-KIT, its orphan-designated therapy targeting KIT-driven cancers.
GPT-5.3 Instant reduces hallucinations by 26.8% on web queries and 19.7% on internal knowledge — OpenAI's most-used model now ...
The deal strengthens AWS's AI offerings and may help fend off challenges from cloud rivals Microsoft and Google.