Nucleic acids are complex biological molecules that store and transmit genetic information in all living organisms. They are essential for the survival and reproduction of life on Earth. The two main ...

Endosomal and cytosolic nucleic acid receptors sense microbial nucleic acids and initiate innate immune responses. However, in some circumstances their activation by endogenous nucleic acids can also ...

Since the discovery of the double-helical structure of DNA and postulation of the central dogma of molecular biology, stating that the flow of genetic information goes from DNA to RNA to protein, the ...

Our research focuses on all aspects of nucleic acid structure, chemistry and function employing state of the art technologies and approaches. The structure and chemistry of nucleic acids is ...

The Nucleic Acids Institute is dedicated to understanding the chemical and biological basis for nucleic acid function, and to developing new and powerful nucleic acids based therapeutic and ...

The chemical origin of life on Earth is a puzzle that scientists have been trying to piece together for decades. Many hypotheses have been proposed to explain how life came to be and what chemical and ...

Thioguanosine (shown as S in the sequence) is placed at nearby, non-complementary positions within a DNA duplex. When exposed to light or mild oxidants, the modified bases react to form a disulfide ...

DNA, the blueprint of life, is best known for its fundamental role as genetic material—storing and transmitting biological information through the precise sequence of its bases. For decades, this ...

Nucleic acids are chains of nucleotides that are a vital part of all living beings. The two most common types of nucleic acids are deoxyribonucleic acid (DNA) and ribonucleic acid (RNA), which provide ...

A recent study utilizing cryo-EM advances our understanding of how bacterial immune systems function and reveals new aspects ...