The genomes of large numbers of single cells must be sequenced to further understanding of the biological significance of genomic heterogeneity in complex systems. Whole genome amplification (WGA) of ...

What is multiple cross displacement amplification? Multiple cross displacement amplification (MCDA) method uses random primers and DNA polymerase to amplify the circular DNA template. The DNA can be ...

Applications that need accurate replication often require large amounts of high-quality DNA for analysis and archiving. Areas where high fidelity, low mutation whole genome amplification (WGA) is ...

The study of bacterial populations using whole-genome sequencing is of considerable scientific and clinical interest. However, obtaining bacterial genomic information is not always trivial: the target ...

Karyomapping, a technique for preimplantation genetic diagnosis (PGD) of single gene disorders, involves using very few or single cells, and comes with challenges due to limited amounts of sample DNA.

Template-independent amplification is a major artifact affecting multiple displacement amplification of minute amounts of DNA. A novel modification of this isothermal amplification method now strongly ...