The primary role of Mouse Genetics Core Facility (MGCF) is to facilitate the use of mouse molecular genetics at MSK for in vivo studies of gene functions germane to cancer. Relevant fields in which ...

After 5-10 generations of inbreeding, mouse colonies should be “refreshed”, to remove or prevent genetic drift accumulation in the colony. Several methods to refresh the genetic background may include ...

Developing treatments aimed at the causes of diseases such as cancer, infections and metabolic, autoimmune and psychiatric disorders requires knowledge of the underlying biological mechanisms. Such ...

There is general appreciation that 'genetic background effects' can profoundly affect the immune phenotypes of congenic, transgenic and knockout mice. We suggest that attributing phenotypes to genetic ...