DNA, the genetic material compacted in chromosomes, stores information to regulate all the cell processes in the body. Two decades ago, in addition to the widely known Watson-Crick double helix model ...

“[...] we present an improved method for G4 landscape determination and by applying it we show that sequence property-specific constraints of the nuclear ...

Not all DNA looks like the familiar twisted ladder. Sometimes, parts of our genetic code fold into unusual shapes. One such structure, the G-quadruplex (G4), looks like a knot. These knots can play ...

G-quadruplexes (G4s) are non-canonical structures formed by guanine-rich nucleic acids, increasingly implicated in transcriptional control, replication dynamics and genome stability at telomeres and ...

Transform how we determine biomolecular structures. This PhD develops generative AI tools that use minimal NMR data to rapidly predict 3D G-quadruplex DNA/RNA structures – a major leap beyond ...