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Genetic model reveals a form of calcium release is unnecessary for normal muscle contraction
Instead, CICR acts as a dormant but dangerous silent risk factor, staying quiet under normal conditions yet becoming a major driver of pathology when RyR1 signaling is disrupted. This model resolves a ...
The mechanism of skeletal muscle contraction is a process that relies on calcium signaling. However, the physiological role of calcium-induced calcium release (CICR) through the ryanodine receptor ...
Researchers engineered mice with a mutation (E3896A) in the RyR1 calcium-binding site, eliminating calcium-induced calcium release (CICR) without affecting depolarization-induced calcium release. The ...
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