A research team from the University of California, Irvine has revealed a previously unknown mechanism that triggers an inflammatory immune response in cells when their DNA is damaged. This discovery ...

A research team has successfully identified a novel DNA damage repair pathway in human cells. This study is the first to discover that proteins present in the nuclear membrane of cells directly ...

Irvine, Calif., Jan. 6, 2025 — A research team from the University of California, Irvine has revealed a previously unknown mechanism that triggers an inflammatory immune response in cells when their ...

Clinical and Preclinical Activity of EGFR Tyrosine Kinase Inhibitors in Non–Small-Cell Lung Cancer Harboring BRAF Class 3 Mutations This was a phase II multicenter trial in which refractory solid ...

Validation of a 15-Gene Prognostic Signature in Metastatic Clear Cell Renal Cell Carcinoma Despite the significance of immune checkpoint inhibitors (ICIs) in solid tumor treatment, identifying ...

Extending their collaboration, Genialis and Debiopharm continue working towards a patient classifier to support WEE1 clinical development BOSTON--(BUSINESS WIRE)-- Genialis, the RNA biomarker company, ...

Extrachromosomal DNA (ecDNA) is a unique form of circular DNA that exists outside of normal chromosomes. Found exclusively in tumor cells, it often carries cancer-promoting genes (oncogenes) and is ...

Scientific consensus on the biological mechanisms underpinning sunburn has remained largely unchanged for decades. The ...

Our DNA is not indestructible. Throughout the course of our lives, DNA can break in response to natural and environmental factors. Thankfully, our bodies have dedicated enzymes and pathways which can ...