In the cerebral cortex, extrinsic and intrinsic excitatory glutamatergic pathways terminate on principal glutamatergic neurons and local inhibitory GABAergic interneurons. Activation of these pathways ...

The brain’s rules seem simple: Fire together, wire together. When groups of neurons activate, they become interconnected. This networking is how we learn, reason, form memories, and adapt to our world ...

Proceedings of the National Academy of Sciences of the United States of America, Vol. 118, No. 34 (August 24, 2021), pp. 1-9 (9 pages) Dendrites play an essential role in the integration of highly ...

Microglia respond to proteinopathies by changing their shapes and expression profiles in different ways. Here’s one that has been somewhat overlooked: rod-shaped microglia. These long, straight cells ...

Shedding light on how the brain fine-tunes its wiring during learning, a new study finds that different dendritic segments of a single neuron follow distinct rules. The findings challenge the idea ...

The result is a dizzyingly complicated network that is in a constant state of flux, rewiring itself on the fly in response to its environment and the life experience of its owner. The brain’s ability ...

Breakthroughs, discoveries, and DIY tips sent six days a week. Terms of Service and Privacy Policy. One of the brain’s most important properties is its flexibility ...